|
Treatment Groups in Patients with Mucosal Leishmaniasis (Peru) |
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| Cohort |
N |
Treatment |
Timing of Treatment |
|
|
|
||||
| Study Injections |
Pentavalent Antimony (Sb5+) |
|||
|
|
||||
| # 1 |
12 4 |
5 μg Leish-111f in 25 μg MPL-SE + Sb5+ Placebo (saline) + Sb5+ |
Day 0, Day 28 and Day 56 |
SSC1 |
| # 2* |
12 4 |
10 μg Leish-111f in 25 μg MPL-SE + Sb5+ Placebo (saline) + Sb5+ |
Day 0, Day 28 and Day 56 |
SSC1 |
| # 3** |
12 4 |
20 μg Leish-111f in 25 μg MPL-SE + Sb5+ Placebo (saline) + Sb5+ |
Day 0, Day 28 and Day 56 |
SSC1 |
|
1SSC = Standard single cycle: 28 days of pentavalent antimony (20 mg/kg IV once daily) starting on Day 0. Sequential enrollment of cohorts: * = after Day 84 of cohort 1; ** = after Day 84 of cohort 2. | ||||
Ghalib and Modabber Kinetoplastid Biology and Disease 2007 6:7 doi:10.1186/1475-9292-6-7 |
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