Table 2

Association of Her-2, ER, and PgR expression and age of the patients and the pathobiological characteristics of the breast tumours. Total number of cases = 166. *p value < 0.005.

Her-2+ve
 Her-2-ve
 ER+ve
 ER-ve
 PgR+ve
 PgR-ve

N.
 %
 N.
 %
 N.
 %
 N.
 %
 N.
 %
 N.
 %
Age of the patients
<30
 3
 *75
 1
 25
 1
 25
 3
 *75
 2
 50
 2
 50
30–55
 89
 *78.8
 24
 21.2
 21
 18.6
 92
 *81.4
 53
 46.9
 60
 53.1
>55
 23
 46.9
 26
 53.1
 30
 61.2
 19
 38.8
 29
 59.1
 20
 40.8
PATHOBIOLOGICAL CHARACTERISTICS OF THE TUMOURS
Tumour location
Right breast
 78
 *87.6
 11
 12.4
 45
 50.6
 44
 49.4
 40
 44.9
 49
 55.1
Left breast
 32
 45.7
 38
 54.3
 34
 48.6
 36
 51.4
 33
 47.1
 37
 52.9
Both
 7
 100
 0
 0
 1
 14.3
 6
 85.7
 3
 42.9
 4
 57.1













Margins
Irregular (stellate)
 130
 *89
 16
 11
 26
 17.8
 120
 *82.2
 70
 47.9
 76
 52
Defined (demarked)
 9
 45
 11
 55
 10
 50
 10
 50
 11
 55
 9
 45













Operation performed
Total mastectomy with axillary clearance
 84
 *94.4
 5
 5.6
 11
 12.4
 78
 *87.6
 14
 15.7
 75
 *84.3
Total lumpectomy without axillary clearance
 25
 51.0
 24
 49.0
 27
 55.1
 22
 44.9
 26
 53.1
 23
 46.9
Total mastectomy without axillary clearance
 10
 58.8
 7
 41.2
 8
 47.1
 9
 52.9
 9
 52.9
 8
 47.1
Total lumpectomy with axillary clearance
 7
 *100
 0
 0
 2
 28.6
 5
 *71.4
 1
 14.3
 6
 *85.7
Total quadrantectomy
 2
 50
 2
 50
 2
 50
 2
 50
 2
 50
 2
 50













Type
Invasive carcinoma
 120
 *87
 18
 13
 28
 20.3
 110
 *79.7
 40
 29
 98
 *71
Non-invasive carcinoma
 2
 7.1
 26
 *92.9
 24
 *85.7
 4
 14.3
 20
 *71.4
 8
 28.6













Surrounding breast tissue
Adenosis
 40
 47.1
 45
 52.9
 42
 49.4
 43
 50.6
 46
 54.1
 39
 45.9
Fibrocystic
 65
 *89.0
 8
 11.0
 13
 17.8
 60
 *82.2
 31
 42.5
 42
 57.5
Normal
 0
 0
 6
 100
 1
 16.7
 5
 83.3
 3
 50
 3
 50
Papillomatous
 1
 50
 1
 50
 1
 50
 1
 50
 1
 50
 1
 50













Mitotic index
<10
 6
 21.4
 22
 *78.6
 19
 *67.9
 9
 32.1
 20
 *71.4
 8
 28.6
10–20
 79
 *86.8
 12
 13.2
 14
 15.4
 77
 *84.6
 51
 56.0
 40
 44.0
>20
 42
 *89.4
 5
 10.6
 7
 14.9
 40
 *85.1
 26
 55.3
 21
 44.7













Nuclear pleomorphism
Small
 4
 22.2
 14
 *77.8
 12
 *66.7
 6
 33.3
 11
 *61.1
 7
 38.9
Moderate
 30
 46.9
 34
 53.1
 36
 56.2
 28
 43.7
 33
 51.6
 31
 48.4
Marked
 76
 *90.5
 8
 9.5
 9
 10.7
 75
 *89.3
 44
 52.4
 40
 47.6













Grade
I
 1
 5.9
 16
 *94.1
 14
 *82.3
 3
 17.6
 10
 58.8
 7
 41.2
II
 78
 *92.9
 6
 7.1
 4
 4.8
 80
 *95.2
 40
 47.6
 44
 52.4
III
 57
 *87.7
 8
 12.3
 10
 15.4
 55
 *84.6
 33
 50.8
 32
 49.2













Size (cm)
<2
 7
 28
 18
 *72
 20
 *80
 5
 20
 14
 56
 11
 44
2–5
 75
 *84.3
 14
 15.7
 17
 19.1
 72
 *80.9
 29
 32.6
 60
 *67.4
>5
 48
 *92.3
 4
 7.7
 6
 11.5
 46
 *88.5
 12
 23.1
 40
 *76.9













Tumour lymphocytes
Absent
 26
 45.6
 31
 54.4
 29
 50.9
 28
 49.1
 35
 61.4
 22
 38.6
Scanty
 20
 46.5
 23
 53.5
 25
 58.1
 18
 41.9
 24
 55.8
 19
 44.2
Multifocal outside the tumour
 8
 44.4
 10
 55.6
 9
 50
 9
 50
 11
 61.1
 7
 38.9
Band outside the tumour
 6
 46.1
 7
 53.8
 8
 61.5
 5
 38.5
 9
 69.2
 4
 30.8
Multifocal within the tumour
 5
 45.4
 6
 54.5
 7
 63.6
 4
 36.4
 6
 54.5
 5
 45.4
Diffuse outside the tumour
 7
 63.6
 4
 36.4
 6
 54.5
 5
 45.4
 7
 63.6
 4
 36.4
Diffuse within the tumour
 3
 42.9
 4
 57.1
 3
 42.9
 4
 57.1
 5
 71.4
 2
 28.6
Band within the tumour
 5
 83.3
 1
 16.7
 1
 16.7
 5
 83.3
 3
 50
 3
 50













Stage
I
 6
 21.4
 22
 *78.6
 19
 *67.9
 9
 32.1
 16
 57.1
 12
 42.9
II
 34
 51.5
 32
 48.5
 30
 45.4
 36
 54.5
 28
 42.4
 38
 57.6
III
 39
 *81.2
 9
 18.7
 7
 14.6
 41
 *85.4
 22
 45.8
 26
 54.2
IV
 21
 *87.5
 3
 12.5
 6
 25
 18
 *75
 14
 58.3
 10
 41.7













Histological types of non-invasive carcinoma
Ductal carcinoma in situ (DCIS)
 18
 *78.3
 5
 21.7
 7
 30.4
 16
 *69.6
 11
 47.8
 12
 52.2
Lobular carcinoma in situ (LCIS)
 3
 60
 2
 40
 2
 40
 3
 60
 3
 60
 2
 40













Histological subtypes of ductal carcinoma in situ (DCIS)
Comedo
 9
 *81.8
 2
 18.2
 3
 27.3
 8
 *72.7
 6
 54.5
 5
 45.4
Cribriform
 5
 *83.3
 1
 16.7
 1
 16.7
 5
 *83.3
 3
 50
 3
 50
Solid
 1
 50
 1
 50
 1
 50
 1
 50
 2
 100
 0
 0
Papillary
 0
 0
 2
 100
 2
 100
 0
 0
 1
 50
 1
 50
Micropapillary
 0
 0
 1
 100
 1
 100
 0
 0
 0
 0
 1
 100
Apocrine
 0
 0
 1
 100
 1
 100
 0
 0
 1
 100
 0
 0













Histological subtypes of invasive carcinoma
Ductal – not otherwise specified
 89
 *89.9
 10
 10.1
 13
 13.1
 86
 *86.9
 44
 44.4
 55
 55.6
Lobular
 13
 *92.9
 1
 7.1
 2
 14.3
 12
 *85.7
 8
 57.1
 6
 42.9
Tubular/cribriform
 3
 23.1
 10
 *76.9
 11
 *84.6
 2
 15.4
 5
 38.5
 8
 *61.5
Colloid (mucinous)
 0
 0
 2
 100
 1
 50
 1
 50
 1
 50
 1
 50
Medullary
 2
 100
 0
 0
 0
 0
 2
 100
 1
 50
 1
 50
Papillary
 1
 50
 1
 50
 1
 50
 1
 50
 2
 100
 0
 0
Comedo
 2
 100
 0
 0
 0
 0
 2
 100
 1
 50
 1
 50
Paget's disease
 0
 0
 1
 100
 0
 0
 1
 100
 0
 0
 1
 100
Adenoid
 0
 0
 1
 100
 1
 100
 0
 0
 1
 100
 0
 0
Apocrine
 0
 0
 1
 100
 1
 100
 0
 0
 1
 100
 0
 0

Saleh and Abdeen Journal of Carcinogenesis 2007 6:12   doi:10.1186/1477-3163-6-12