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The oxanorbornene approach to 3-hydroxy, 3,4-dihydroxy and 3,4,5-trihydroxy derivatives of 2-aminocyclohexanecarboxylic acid

Ishmael B Masesane1,2*, Andrei S Batsanov1, Judith AK Howard1, Raju Mondal1 and Patrick G Steel1

Author Affiliations

1 Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK

2 Department of Chemistry, University of Botswana, P/bag 00704, Gaborone, Botswana

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Beilstein Journal of Organic Chemistry 2006, 2:9 doi:10.1186/1860-5397-2-9

Published: 4 May 2006

Abstract

The nitro oxanorbornene adduct derived from the Diels-Alder reaction of ethyl (E)-3-nitroacrylate and furan provides a versatile template for the stereoselective synthesis of hydroxylated derivatives of 2-aminocyclohexanecarboxylic acid (ACHC).

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