|
Base-induced cyclization of 7. |
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| entry |
cond.a |
Ar Yield [%]: |
8 |
9 |
10 |
|
|
|||||
| 1 |
A |
a (phenyl) |
22 |
63 |
- |
| 2 |
B |
a (phenyl) |
13 |
42 |
- |
| 3 |
C |
a (phenyl) |
8 |
60 |
28 |
| 4 |
A |
b (4-tolyl) |
42 |
36 |
- |
| 5 |
B |
b (4-tolyl) |
9 |
60 |
- |
| 6 |
C |
b (4-tolyl) |
30 |
36 |
9 |
| 7 |
A |
c (4-anisyl) |
36 |
10 |
- |
| 8 |
B |
c (4-anisyl) |
25 |
50 |
- |
|
Isolated yields are given. a) Reaction conditions: 1 equiv. NaH, 90 min room temperature, concentration ~30 mmol/L; A: in THF, B: in DMF, C: in DMF in the presence of air. | |||||
Dyker et al. Beilstein Journal of Organic Chemistry 2007 3:28 doi:10.1186/1860-5397-3-28 |
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