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Total synthesis of quinolizidine alkaloid (-)-217A. Application of iminoacetonitrile cycloadditions in organic synthesis.

Maloney KM, Danheiser RL.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.

[reaction: see text] An intramolecular iminoacetonitrile [4 + 2] cycloaddition functions as the key step in an efficient total synthesis of the quinolizidine alkaloid (-)-217A.

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PMID: 15987219 [PubMed - indexed for MEDLINE]